Absence of chicken myelin basic protein residues in commercial formulations of MMR vaccine

Several preparations of MMR vaccines and their progenitor monovalent vaccin e bulks produced by two different manufacturers were examined serologically for the presence of chicken myelin basic protein (MBP) residues. The produ cts were challenged against several commercial preparations of anti-hMBP an tisera that reacted positively with the control MBP preparations of human a nd chicken origins. There was no evidence of the presence of MBP components in MMR vaccines or their progenitor vaccine bulks as shown by the reactivi ty profiles of the antibody preparations against control and test antigens. (C) 2000 Elsevier Science Ltd. All rights reserved.