ELECTROPHYSIOLOGICAL AND ANTIARRHYTHMIC E FFECTS OF A NEW CLASS-III ANTIARRHYTHMIC DRUG NIBENTAN IN PATIENTS WITH PAROXYSMAL VENTRICULAR-TACHYCARDIA

Authors
MAYKOV EB BAKLANOV SA KRUTANOV IB GOLITSIN SP RUDA MY ROSENSHTRAUKH LV CHAZOV EI
Citation
Eb. Maykov et al., ELECTROPHYSIOLOGICAL AND ANTIARRHYTHMIC E FFECTS OF A NEW CLASS-III ANTIARRHYTHMIC DRUG NIBENTAN IN PATIENTS WITH PAROXYSMAL VENTRICULAR-TACHYCARDIA, Kardiologia, 37(4), 1997, pp. 16-27
Citations number
45
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Kardiologia → ACNP
ISSN journal
00229040
Volume
37
Issue
4
Year of publication
1997
Pages
16 - 27
Database
ISI
SICI code
0022-9040(1997)37:4<16:EAAEFO>2.0.ZU;2-R
Abstract
Electrophysiological and antiarrhythmic effects of a novel class III a ntiarrhythmic drug nibentan were studied in 10 patients with paroxysma l ventricular tachycardia. After intravenous injection of nibentan (0, 125 mg/kg) prolongation of QT and QT(c) intervals, significant increas es of right atrial, right ventricular and His-Purkinje system's effect ive refractory period were observed. Antiarrhythmic activity of nibent an in relation to reproducible at endocardial pacing paroxysmal ventri cular tachycardia was 80%. In 1 patient arrhythmogenic effect of the d rug - polymorphic ventricular tachycardia (torsade de pointes) - was r egistered.