Endoscopic biopsy is an important tool for histological diagnosis of lesion
s residing in gastrointestinal tracts. However, it is less useful in submuc
osal lesions due to the existence of normal overlying mucosa. We developed
a new and safe technique for the diagnosis of submucosal tumor using Stiegm
ann-Goff endoscopic ligator. After removing surface mucosa to expose submuc
osal tissue by this method, conventional secured histological diagnosis cou
ld be performed. To determine definitive histological diagnosis, this techn
ique is useful as well as Endoscopic Ultrasound (EUS) with fine needle aspi
ration biopsy anti other modalities.