C. Binnert et al., Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans, AM J P-ENDO, 279(5), 2000, pp. E1072-E1079
Citations number
34
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Fatty acid transporter protein (FATP)-1 mRNA expression was investigated in
skeletal muscle and in subcutaneous abdominal adipose tissue of 17 healthy
lean, 13 nondiabetic obese, and 16 obese type 2 diabetic subjects. In musc
le, FATP-1 mRNA levels were higher in lean women than in lean men (2.2 +/-
0.1 vs. 0.6 +/- 0.2 amol/mug total RNA, P < 0.01). FATP-1 mRNA expression w
as decreased in skeletal muscle in obese women both in nondiabetic and in t
ype 2 diabetic patients (P < 0.02 vs. lean women in both groups), and in al
l women there was a negative correlation with basal FATP-1 mRNA level and b
ody mass index (r = -0.74, P < 0.02). In men, FATP-1 mRNA was expressed at
similar levels in the three groups both in skeletal muscle (0.6 +/- 0.2, 0.
6 +/- 0.2, and 0.8 +/- 0.2 amol/<mu>g total RNA in lean, obese, and type 2
diabetic male subjects) and in adipose tissue (0.9 +/- 0.2 amol/mug total R
NA in the 3 groups). Insulin infusion (3 h) reduced FATP-1 mRNA levels in m
uscle in lean women but not in lean men. Insulin did not affect FATP-1 mRNA
expression in skeletal muscle in obese nondiabetic or in type 2 diabetic s
ubjects nor in subcutaneous adipose tissue in any of the three groups. Thes
e data show a gender-related difference in the expression of the fatty acid
transporter FATP-1 in skeletal muscle of lean individuals and suggest that
changes in FATP-1 expression may not contribute to a large extent to the a
lterations in fatty acid uptake in obesity and/or type 2 diabetes.