No tissue damage by chronic deep brain stimulation in Parkinson's disease

Authors
Haberler, C Alesch, F Mazal, PR Pilz, P Jellinger, K Pinter, MM Hainfellner, JA Budka, H
Citation
C. Haberler et al., No tissue damage by chronic deep brain stimulation in Parkinson's disease, ANN NEUROL, 48(3), 2000, pp. 372-376
Citations number
17
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
48
Issue
3
Year of publication
2000
Pages
372 - 376
Database
ISI
SICI code
0364-5134(200009)48:3<372:NTDBCD>2.0.ZU;2-K
Abstract
We report on the pathological findings in the brains of 8 Parkinson's disea se patients treated with deep brain stimulation (DBS) of the thalamic ventr al intermediate nucleus (6 cases) and subthalamic nucleus (2 cases). DBS wa s performed continuously for up to 70 months. AU brains showed well-preserv ed neural parenchyma and only mild gliosis around the lead track compatible with reactive changes due to surgical placement of the electrode. We concl ude that chronic DBS does not cause damage to adjacent brain tissue.