Gene polymorphism affecting alpha 1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

Authors
Licastro, F Pedrini, S Ferri, C Casadei, V Govoni, M Pession, A Sciacca, FL Veglia, F Annoni, G Bonafe, M Olivieri, F Franceschi, C Grimaldi, LME
Citation
F. Licastro et al., Gene polymorphism affecting alpha 1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk, ANN NEUROL, 48(3), 2000, pp. 388-391
Citations number
20
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
ANNALS OF NEUROLOGY
ISSN journal
03645134 → ACNP
Volume
48
Issue
3
Year of publication
2000
Pages
388 - 391
Database
ISI
SICI code
0364-5134(200009)48:3<388:GPAA1A>2.0.ZU;2-J
Abstract
Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 bet a) were increased in patients with probable Alzheimer's disease (AD). A com mon polymorphism within ACT and IL-IP genes affected plasma levels of ACT o r IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype sho w-ed the highest levels of plasma ACT or IL-1 beta, respectively. The conco mitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the ri sk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreas ed the age at onset of the disease.