Isolation and characterization of tetracycline-resistant clinical isolatesof Helicobacter pylori

Authors
Kwon, DH Kim, JJ Lee, M Yamaoka, Y Kato, M Osato, MS El-Zaatari, FAK Graham, DY
Citation
Dh. Kwon et al., Isolation and characterization of tetracycline-resistant clinical isolatesof Helicobacter pylori, ANTIM AG CH, 44(11), 2000, pp. 3203-3205
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
11
Year of publication
2000
Pages
3203 - 3205
Database
ISI
SICI code
0066-4804(200011)44:11<3203:IACOTC>2.0.ZU;2-0
Abstract
Tetracycline is an important component of combination therapies for Helicob acter pylori eradication. Twenty-nine tetracycline-resistant isolates requi ring MICs ranging from 4 to 16 mug/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracyclin e-resistant isolates exhibited cross-resistance to metronidazole, and the c ross-resistance was transferred to tetracycline-sensitive H. pylori strains .