PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages

Authors
Martin, M Serradji, N Dereuddre-Bosquet, N Le Pavec, G Fichet, G Lamouri, A Heymans, F Godfroid, JJ Clayette, P Dormont, D
Citation
M. Martin et al., PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages, ANTIM AG CH, 44(11), 2000, pp. 3150-3154
Citations number
32
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
11
Year of publication
2000
Pages
3150 - 3154
Database
ISI
SICI code
0066-4804(200011)44:11<3150:PANPFR>2.0.ZU;2-B
Abstract
We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vi tro of new platelet-activating factor (PAF) receptor antagonists, as PAF an d viral replication are thought to be involved in HN neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV rep lication in macrophages and potentiated the antiretroviral activity of zido vudine. These results suggest that PMS-601 is of potential value as an adju vant treatment for HIV infection.