Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains

Authors
Novelli, A Fallani, S Cassetta, MI Conti, S Mazzei, T
Citation
A. Novelli et al., Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains, ANTIM AG CH, 44(11), 2000, pp. 3174-3176
Citations number
22
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
11
Year of publication
2000
Pages
3174 - 3176
Database
ISI
SICI code
0066-4804(200011)44:11<3174:PLEOMA>2.0.ZU;2-O
Abstract
The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in co mparison with that of imipenem was evaluated with 24 recently isolated gram -positive and gram-negative strains. In general, preexposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell ph agocytic killing. The PALE of imipenem was generally significantly less tha n that observed with meropenem.