We describe the use of low-coherence interferometry (LCI) for the structura
l characterization of nonuniform media with mesoscopic heterogeneities. The
high sensitivity of LCI to the phase properties of scattered light makes i
t a suitable technique for the direct determination of size, concentration,
and uniformity of heterogeneities in multi-phase systems. To demonstrate t
his, we examine using LCI to study a range of polystyrene microsphere suspe
nsions with particle sizes ranging from 41 to 818 nm and concentrations fro
m 0.25% to 10% by weight. The particle size and concentration information w
as extracted from the amplitude of the signal by using the theory of light
scattering in nonuniform media. We have shown that the fluctuations in the
unaveraged LCI signal may be utilized to extract additional information abo
ut system uniformity.