Total synthesis of a demethoxy-egonol from Styrax obassia

Authors
Choi, HD Ha, MC Seo, PJ Son, BW Song, JC
Citation
Hd. Choi et al., Total synthesis of a demethoxy-egonol from Styrax obassia, ARCH PH RES, 23(5), 2000, pp. 438-440
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
438 - 440
Database
ISI
SICI code
0253-6269(200010)23:5<438:TSOADF>2.0.ZU;2-V
Abstract
The total synthesis of a demethoxy-egonol isolated from Styrax obassia, 5-( 3-hydroxypropyl)-2-(3',4'-methylenedioxyphenyl)benzofuran (9), is described . The key steps involve the construction of a 2-arylbenzofuran skeleton 7 f rom methyl 3-(4-hydroxyphenyl)propionate with 2-chloro-2-methylthio-(3',4'- methylenedioxy)acetophenone (6) in the presence of ZnCl2 and successive des ulfurization of the resulting product 7.