Drug treatment remains an active domain in the therapy of male fertility di
sorders. Although there are only a few conditions that allow causal treatme
nt, rational approaches are possible in many cases. Best results are obtain
ed in cases requiring an anti-inflammatory treatment and in patients with a
n impaired sperm transport. High-dosage administration of FSH is a promisin
g new development, aimed particularly at improving the disturbed sperm stru
ctures. A careful diagnostic work-up with elucidation of the underlying dis
ease is essential to achieve a successful therapy.