Quantitative and qualitative changes in serum luteinizing hormone after injectable testosterone undecanoate treatment in hypogonadal men

Citation
Yq. Gu et al., Quantitative and qualitative changes in serum luteinizing hormone after injectable testosterone undecanoate treatment in hypogonadal men, ASIAN J AND, 2(1), 2000, pp. 65-71
Citations number
25
Categorie Soggetti
Reproductive Medicine
Journal title
ASIAN JOURNAL OF ANDROLOGY
ISSN journal
1008682X → ACNP
Volume
2
Issue
1
Year of publication
2000
Pages
65 - 71
Database
ISI
SICI code
1008-682X(200003)2:1<65:QAQCIS>2.0.ZU;2-4
Abstract
To clarify the immune-active LH (i-LH) and bioactive LH (b-LH) responses an d qualitative changes in the circulating LH to testosterone undecanoate (TU ) injection. Methods: Eight men with Klinefelter's syndrome were recruited for the study. They received crossover injections of TU at doses of 500 and 1000 mg. Serum i-LH and b-LH levels before and at various time intervals a fter TU injection were measured and the serum i-LH, b-LH, b-LH/i-LH (B/I) a nd testosterone/sex hormone-binding globulin (T/SHBG) ratio in LH-responder s and LH non-responders were compared. Results: A parallel suppression of s erum I-LH and b-LH was consistent with their overall high correlation betwe en each other (r=0.84, P <0.001). Mean serum i-FSH levels were decreased by TU injection at both doses without dose-response effects. LH-responders ha d lower baseline serum i-LH and b-LH, and higher E-2 levels and T/ SHBG rat io. There was a quantitative change in serum LH as induced by TU without qu alitative change within LH-responders os LH-non-responders. Conclusion: A h igh loading dose (1000 mg) of TU is important for the initial suppression o f LH. With the lower dose (500 mg), repeated injections will be required to attain such LH suppression for the purpose of fertility regulation. The lo wer baseline serum i-LH level may be an intrinsic characteristic of LH-resp onders.