Potential GABAB receptor antagonists. XI - Synthesis of a small library ofsulfonamide analogues

Authors
Millan, DS Prager, RH
Citation
Ds. Millan et Rh. Prager, Potential GABAB receptor antagonists. XI - Synthesis of a small library ofsulfonamide analogues, AUST J CHEM, 53(7), 2000, pp. 615-618
Citations number
19
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
53
Issue
7
Year of publication
2000
Pages
615 - 618
Database
ISI
SICI code
0004-9425(2000)53:7<615:PGRAX->2.0.ZU;2-W
Abstract
The synthesis of a small library of 3-heteroarylaminopropane-1-sulfonamide analogues of 4-aminobutanoic acid (GABA) by solid-phase chemistry is report ed. None showed any significant activity as agonists or antagonists of GABA (A) or GABA(B) receptors in the guinea pig ileum.