Y. Arinobu et al., Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells, BIOC BIOP R, 277(2), 2000, pp. 317-324
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Signal transducer and activation of transcription (STAT)6 has a central rol
e in the signal transduction of interleukin (IL)-4 and IL-13. It has recent
ly been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed
ubiquitously; however, it remains unknown how STAT6 and STAT3 expression i
s regulated. In this study, we found that STAT6 expression was augmented at
the transcription level in B and T cells stimulated with anti-IgM antibody
and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3
expression was similarly augmented in the stimulated B cells. The stimulate
d B and T cells showed enhancement of STAT6 activation and CD23 expression
induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mecha
nism of the amplification of the IL-4 and IL-13 signals in stimulated B and
T cells. (C) 2000 Academic Press.