The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells

Authors
Li, X Wang, Y Debatin, KM Hug, H
Citation
X. Li et al., The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells, BIOC BIOP R, 277(2), 2000, pp. 513-517
Citations number
16
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
277
Issue
2
Year of publication
2000
Pages
513 - 517
Database
ISI
SICI code
0006-291X(20001022)277:2<513:TSKHIW>2.0.ZU;2-I
Abstract
HIPK2 has been described as a homoedomain-interacting protein kinase with a nuclear localization. Here we describe that HIPK2 can also associate with TRADD, a protein that interacts with tumor necrosis factor receptor type 1 (TNF-R1). Under the conditions where HIPK2/TRADD association was found, no direct interaction of HIPK2 with CD95, TNF-R1, FADD or caspase-8 could be d etected. Therefore, HIPK2 may play a role in TNF-R1 mediated signaling. (C) 2000 Academic Press.