Cardiac toxicity following high-dose cyclophosphamide, cisplatin, and BCNU(STAMP-I) for breast cancer

We retrospectively evaluated 443 breast cancer patients treated with high-d ose cyclophosphamide, cisplatin, and BCNU (STAMP-I) with autologous stem ce ll support to characterize the cardiac toxicity of this regimen. Patients h ad stage II-III (n = 243) or stage IV (n = 200) breast cancer. We observed an overall 5.1% incidence of cardiac complications, both clinical and subcl inical, in the whole group: 4.9% in stage II-III and 5.5% in stage TV patie nts. Clinical cardiomyopathy (CR IP) was observed in 1.6% of stage II-III p atients (1 case of fatal grade 5 toxicity and 3 cases of grade 3 CMP) and i n 3.5% of patients with stage TV disease (1 case of grade 4 and 6 cases of grade 3). The incidence of cardiac toxicity did not differ significantly be tween the groups. Prior radiation therapy to the mediastinum or left chest wall (P = .001) and advanced age (P = .01) were independent predictors of a n increased risk of the appearance of this complication. No pharmacodynamic correlation was observed between any of the 3 drugs and cardiac toxicity.