Successful treatment of severe hemorrhagic cystitis with cystectomy following matched donor allogeneic hematopoietic cell transplantation

We report a case of severe hemorrhagic cystitis complicating high-dose cycl ophosphamide (CY), total body irradiation and allogeneic hematopoietic stem cell transplantation (HSCT), Supportive care with i.v. hydration, platelet transfusions, continuous bladder irrigation and aluminum irrigation of the bladder was ineffective and the patient developed multiple complications f rom hemorrhagic cystitis. His condition became critical with persistent ble eding, pulmonary edema and acute renal failure. These problems resolved fol lowing successful simple cystectomy and ileal conduit. The patient did not develop any acute or chronic complications following surgery. He is alive w ith a good quality of life and in third remission after receiving salvage c hemotherapy 14 months after his transplantation.