Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile(105)Val polymorphism

Authors
Sweeney, C McClure, GY Fares, MY Stone, A Coles, BF Thompson, PA Korourian, S Hutchins, LF Kadlubar, FF Ambrosone, CB
Citation
C. Sweeney et al., Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile(105)Val polymorphism, CANCER RES, 60(20), 2000, pp. 5621-5624
Citations number
19
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
00085472 → ACNP
Volume
60
Issue
20
Year of publication
2000
Pages
5621 - 5624
Database
ISI
SICI code
0008-5472(20001015)60:20<5621:ABSATF>2.0.ZU;2-E
Abstract
A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile(105)Val; the Val-containing enzyme has reduced activity t oward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy, We evaluated su rvival according to GSTP1 genotype among women (a = 240) treated Pur breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% con fidence interval, 0.5-1.3) for Ile/Val and 0.3 (95% confidence interval, 0. 1-1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability ma y influence treatment outcomes.