Targeting aerosol deposition in patients with cystic fibrosis - Effects ofalterations in particle size and inspiratory flow rate

Study objective: To determine if aerosolized medications can be targeted to deposit in the smaller, peripheral airways or the larger, central airways of adult cystic fibrosis (CF) patients by varying particle size and inspira tory flow rate, Design: Randomized clinical trial, Setting: Outpatient research laboratory, Patients: Nine adult patients with CF. Interventions: Patients inhaled an aerosol comprised of 3.68 +/- 0.04 mum s aline solution droplets (two visits) or 1.01 +/- 0.2 mum saline solution dr oplets (two visits) for 30 s, starting from functional residual capacity an d breathing at a slow or faster inspiratory flow rate. On all visits, the s aline solution was admired with the radioisotope Tc-99m, Immediately after inhalation, a gamma camera recorded the deposition pattern of the radioaero sol in the lungs, Deposition images were analyzed in terms of the inner:out er zone (I:O) ratio, a measure of deposition in an inner zone (large, centr al ah-ways) vs an outer zone (small airways and alveoli). Measurements and results; For the 3.68-mum aerosol, I:O ratios averaged 2.2 9 +/- 1.45 and 2.54 +/- 1.48 (p > 0.05), indicating that aerosol distributi on within the lungs was unchanged while breathing at 12 +/- 2 L/min vs 31 /- 5 L/min, respectively, For the 1.01-mum aerosol, I:O ratios averaged 2.0 9 +/- 0.96 and 3.19 +/- 1.95 (p < 0.05), indicating that deposition was pre dominantly in the smaller airways while breathing at 18 <coproduct> 5 L/min and in the larger airways while breathing at 38 +/- 8 L/min, respectively, Conclusions: These results suggest that the targeted delivery of an aerosol to the smaller, peripheral airways or the larger, central airways of adult CF patients may be achieved by generating an aerosol comprised of approxim ately 1.0-mum particles and inspiring from functional residual capacity at approximately 18 L/min and similar to 38 L/min, respectively.