The effect of inflammation on mucociliary clearance in asthma - An overview

Mucociliary clearance (MCC) is one of the most important nonspecific defens e mechanisms of the respiratory tract, and its impairment is a well-documen ted feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the muc ociliary apparatus. Epithelial damage and functional abnormalities have bee n described in bronchial asthma, along with changes in mucus-secreting cell s and the chemical and rheological properties of airway fluid. Although the mechanisms of MCC impairment in asthma are not clearly understood, data in the recent literature suggest that airway inflammation plays a major role. In this article, we review studies on MCC alterations in light of up-to-da te findings on pathogenetic mechanisms in asthma.