Ocular manifestations have been attributed to the Epstein-Barr virus (EBV),
largely on the basis of seroepidemiologic data. Two patients who developed
conjunctival disease as the presenting feature of EBV infection are report
ed, each confirmed by in situ hybridization of EBV genome in affected tissu
e biopsy specimens. Recognition of EBV-induced ocular disease as an initial
presentation of clinical EBV infection is important to the practitioner be
cause of the ubiquitous nature of this herpesvirus.