Central venous catheter-related infections in children on long-term home parenteral nutrition: incidence and risk factors

Background and aims:This study aimed to assess the incidence and etiology o f central venous catheter (CVC) infections in children on home parenteral n utrition (HPN). Methods: 207 CVC-years were studied retrospectively in 47 c hildren on HPN, aged 8.1 +/- 5.0 years. Results: 125 CVC were used (means: 2.6 CVC/patient and 21 months utilization/ CVC). Half of the hospitalizatio ns (162) were due to proven CVC-related infections. The mean infection inci dence was 2.1/1000 HPN days. The total population divided in two groups bel ow and above this value: group one including 24 children, incidence less th an or equal to 2.1 per 1000 days (mean: 0.83) and group two including 23 ch ildren, incidence > 2.1 per1000 days (mean: 4.3). No differences were found between the two groups in terms of underlying disease, presence of ostomie s, age at the time of HPN onset, or micro-organisms responsible. The only d ifferences (p < 0.05) were the mean duration of HPN (longer in group one) a nd the delay between HPN onset and the first infection (longer in group one ). Conclusions: This study does not highlight any risk factors for CVC infe ction. However, early CVC infections after HPN onset appear to predict a ba d prognosis. (C) 2000 Harcourt Publishers Ltd.