Synthesis and crystal structure determination of cyclosporin H

Authors
Jegorov, A Cvak, L Husek, A Simek, P Heydova, A Ondracek, J Pakhomova, S Husak, M Kratochvil, B Sedmera, P Havlicek, V
Citation
A. Jegorov et al., Synthesis and crystal structure determination of cyclosporin H, COLL CZECH, 65(8), 2000, pp. 1317-1328
Citations number
47
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
8
Year of publication
2000
Pages
1317 - 1328
Database
ISI
SICI code
0010-0765(200008)65:8<1317:SACSDO>2.0.ZU;2-0
Abstract
Acid-catalyzed degradation of cyclosporin A was studied in various solvents and products of reaction were monitored by HPLC. Identification of amino a cids and their chirality were determined after hydrolysis and derivatizatio n by GC-MS. Cyclosporin H was isolated as the principal product and its str ucture was determined by X-ray diffraction: Cyclosporin H-diethyl ether-wat er (1:0.5:1) crystallizes in the monoclinic space group I2 with a = 12.338( 2) Angstrom, b = 18.963(2) Angstrom, c = 34.074(3) Angstrom, beta = 96.47(2 )degrees, Z = 4, and V = 7921.4(17) Angstrom (3).