Signature-tagged mutagenesis in the identification of virulence genes in pathogens

Authors
Shea, JE Santangelo, JD Feldman, RG
Citation
Je. Shea et al., Signature-tagged mutagenesis in the identification of virulence genes in pathogens, CURR OPIN M, 3(5), 2000, pp. 451-458
Citations number
57
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
3
Issue
5
Year of publication
2000
Pages
451 - 458
Database
ISI
SICI code
1369-5274(200010)3:5<451:SMITIO>2.0.ZU;2-B
Abstract
Signature-tagged mutagenesis is a functional genomics technique that identi fies microbial genes required for infection within an animal host, or withi n host cells. The application of this technique to a range of microbial pat hogens has resulted in the identification of novel virulence determinants i n each screen performed to date, so that cumulatively several hundred genes have been ascribed a role in virulence.