Stability study of W/O/W viscosified multiple emulsions

Citation
O. Ozer et al., Stability study of W/O/W viscosified multiple emulsions, DRUG DEV IN, 26(11), 2000, pp. 1185-1189
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
26
Issue
11
Year of publication
2000
Pages
1185 - 1189
Database
ISI
SICI code
0363-9045(2000)26:11<1185:SSOWVM>2.0.ZU;2-M
Abstract
Stable multiple emulsions with a small proportion of primary emulsion conta ining different viscosifying agents in the outer aqueous phase were formula ted. The multiple systems were assessed by evaluating several parameters, s uch as the macroscopic aspect, droplet size, release rate, and accelerated stability under elevated temperatures. The effect of different viscosifying agents at different concentrations on the stability and the multiplicity o f the multiple emulsions was examined. The viscosity increased by increasin g the concentration of the viscosifying agents. It also appeared that the v iscosifying agents increased the temperature stability of the multiple emul sions. As a result, the formulation viscosified with Klucel was more stable , while the one prepared with carbomer viscosified the outer phase at much lower concentrations with much better skin feel.