Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities

Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8 ) were synthesized and rested as anti-inflammatory and analgesic agents. Th e substituents on the aromatic ring were chosen in order to study the influ ence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results all ow drawing some preliminary considerations on structure-activity relationsh ips. (C) 2000 Elsevier Science S.A. All rights reserved.