Building a pharmacophore model for a novel class of antitubercular compounds

Citation
F. Manetti et al., Building a pharmacophore model for a novel class of antitubercular compounds, FARMACO, 55(6-7), 2000, pp. 484-491
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
55
Issue
6-7
Year of publication
2000
Pages
484 - 491
Database
ISI
SICI code
0014-827X(200006/07)55:6-7<484:BAPMFA>2.0.ZU;2-2
Abstract
Starting from a set of 32 antitubercular compounds, for the first time a th ree-dimensional pharmacophore model has been derived through a computationa l approach based on CATALYST software. The model proved to be able to ident ify compounds belonging to classes of molecules already reported as antitub ercular agents. (C) 2000 Elsevier Science S.A. All rights reserved.