The level of typical biomarker of oxidative stress 8-hydroxy-2 '-deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor

The results of this work show a higher level of 8-hydroxy-2 ' -deoxyguanosi ne (8-OH-dG), a typical biomarker of oxidative stress, in uterine myoma tis sues than in their respective tumor-free tissues. The level of this modifie d base was elevated in uterine tissues of premenopausal women when compared with postmenopausal ones. We have also found the correlation between the s ize of the tumor and the amount of 8-OH-dG. These results suggest that estr ogen-produced 8-OH-dG may be one of the factors responsible for the formati on of the myoma, and it may contribute to malignant transformation of myoma cells. (C) 2000 Elsevier Science Inc.