Vascular endothelial growth factor isoforms 121 and 165 are expressed on B-chronic lymphocytic leukemia cells

Authors
Molica, S Santoro, R Digiesi, G Dattilo, A Levato, D Muleo, G
Citation
S. Molica et al., Vascular endothelial growth factor isoforms 121 and 165 are expressed on B-chronic lymphocytic leukemia cells, HAEMATOLOG, 85(10), 2000, pp. 1106-1108
Citations number
10
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
10
Year of publication
2000
Pages
1106 - 1108
Database
ISI
SICI code
0390-6078(200010)85:10<1106:VEGFI1>2.0.ZU;2-M
Abstract
We used flow cytometry to analyze the expression of vascular endothelial gr owth factor (VEGF) on leukemic cells of 11 B-CLL patients using a monoclona l antibody directed against the 121 and 165 isoforms. All patients tested d isplayed a positive reaction for VEGF. Interestingly, mean fluorescence int ensity (MFI) of cases with a progressive pattern of disease was higher than MFI of patients with stable disease. Cellular VEGF-expression may be invol ved in disease progression.