Disappearance of factor VIII inhibitors in a severe hemophilia A neonate after steroid treatment correlated with a cytokine shift toward a T-helper 2pattern

Authors
Vianello, F Zanon, E Zerbinati, P Innella, B Girolami, A
Citation
F. Vianello et al., Disappearance of factor VIII inhibitors in a severe hemophilia A neonate after steroid treatment correlated with a cytokine shift toward a T-helper 2pattern, HAEMATOLOG, 85(10), 2000, pp. 1114-1115
Citations number
4
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
10
Year of publication
2000
Pages
1114 - 1115
Database
ISI
SICI code
0390-6078(200010)85:10<1114:DOFVII>2.0.ZU;2-M
Abstract
Factor VIII inhibitor developed in a neonate with hemophilia A after a few days of prophylactic therapy with recombinant FVIII. Interleukin-2 and inte rleukin-6 expression was evaluated in lymphocytes by ELISA and by mRNA in s itu hybridization. We observed a Th1-type pattern during inhibitor producti on, which shifted toward a Th2 profile after steroid treatment.