IDENTIFICATION OF NOVEL EXPRESSED SEQUENCE TAGS WITHIN THE FHIT GENE LOCUS IN HUMAN-CHROMOSOME REGION 3P14.2

Authors
LUX A BARDENHEUER W MICHAEL D BROCKER F JULICHER K VIETEN L MICHAELIS S SEEBER S OPALKA B SCHUTTE J
Citation
A. Lux et al., IDENTIFICATION OF NOVEL EXPRESSED SEQUENCE TAGS WITHIN THE FHIT GENE LOCUS IN HUMAN-CHROMOSOME REGION 3P14.2, Human genetics, 100(1), 1997, pp. 90-95
Citations number
31
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
100
Issue
1
Year of publication
1997
Pages
90 - 95
Database
ISI
SICI code
0340-6717(1997)100:1<90:IONEST>2.0.ZU;2-M
Abstract
Losses of genetic material within human chromosome regions (HCR) 3p12- p14 and 3p21-p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particula rly Interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA mar kers deleted in several types of human cancer. We here report on tile identification of five novel 'expressed sequence tags' (ESTs) within 3 p14.2 which map proximal to exon 9 of the candidate TSG, FHIT. These E STs may be valuable for elucidation of the supposed TSG content in 3p1 4.2.