Synthesis, characterization and antiinflammatory effects of Cr(III), Mn(II), Fe(III) and Zn(II) complexes with diclofenac sodium

Authors
Singh, A Singh, P
Citation
A. Singh et P. Singh, Synthesis, characterization and antiinflammatory effects of Cr(III), Mn(II), Fe(III) and Zn(II) complexes with diclofenac sodium, I J CHEM A, 39(8), 2000, pp. 874-876
Citations number
19
Categorie Soggetti
Chemistry
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
ISSN journal
03764710 → ACNP
Volume
39
Issue
8
Year of publication
2000
Pages
874 - 876
Database
ISI
SICI code
0376-4710(200008)39:8<874:SCAAEO>2.0.ZU;2-U
Abstract
Complexes of diclofenac sodium, {2-[(2,6-dichlorophenyl)-amino] benzeneacet ic acid monosodium salt}, an antiinflammatory drug, with Cr(III), Mn(II), F e(III) and Zn(II) have been prepared and characterized by elemental analysi s, magnetic susceptibility, molar conductance, electronic and infrared spec troscopy. The drug functions as bidentate anionic ligand. Antiinflammatory effects have been evaluated by carrageenan-induced rat paw oedema test. The complexes of Cr (III) and Zn (II) have been found to be more effective tha n the drug itself.