The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection

Authors
Kunstmann, E Hardt, C Elitok, E Harder, M Suerbaum, S Peitz, U Schmiegel, W Epplen, JT
Citation
E. Kunstmann et al., The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection, INFEC IMMUN, 68(11), 2000, pp. 6493-6495
Citations number
15
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
11
Year of publication
2000
Pages
6493 - 6495
Database
ISI
SICI code
0019-9567(200011)68:11<6493:TNATIS>2.0.ZU;2-0
Abstract
To determine genetic susceptibility factors for Helicobacter pylori infecti on, polymorphic T-cell receptor gene elements were investigated in 203 H. p ylori-infected individuals and 180 uninfected individuals (controls). H. py lori infection is highly associated with individuals homozygous for the non functional TCRBV6S1B element (odds ratio = 5.9; chi (2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0.0006 3).