Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinalepithelial cells

Authors
Mel, SF Fullner, KJ Wimer-Mackin, S Lencer, WI Mekalanos, JJ
Citation
Sf. Mel et al., Association of protease activity in Vibrio cholerae vaccine strains with decreases in transcellular epithelial resistance of polarized T84 intestinalepithelial cells, INFEC IMMUN, 68(11), 2000, pp. 6487-6492
Citations number
31
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
11
Year of publication
2000
Pages
6487 - 6492
Database
ISI
SICI code
0019-9567(200011)68:11<6487:AOPAIV>2.0.ZU;2-B
Abstract
Culture supernatants prepared from reactogenic strains of Vibrio cholerae c ause a decrease in the transcellular epithelial resistance of T84 intestina l cells. This decrease correlates with the presence of hemagglutinin/protea se but not with the presence of other potential accessory toxins or proteas es. These data suggest a possible role for hemagglutinin/protease in reacto genicity, although other factors may also contribute.