Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice

Authors
Wilkinson, KA Martin, TD Reba, SM Aung, H Redline, RW Boom, WH Toossi, Z Fulton, SA
Citation
Ka. Wilkinson et al., Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice, INFEC IMMUN, 68(11), 2000, pp. 6505-6508
Citations number
25
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
11
Year of publication
2000
Pages
6505 - 6508
Database
ISI
SICI code
0019-9567(200011)68:11<6505:LPOTGF>2.0.ZU;2-G
Abstract
Latency-associated peptide of transforming growth factor beta (TGF-beta) (L AP) was used to determine whether in vivo modulation of TGF-beta bioactivit y enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL /6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptib ility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.