Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency withcontinuous positive airway pressure delivered by a face mask - A randomized controlled trial
C. Delclaux et al., Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency withcontinuous positive airway pressure delivered by a face mask - A randomized controlled trial, J AM MED A, 284(18), 2000, pp. 2352-2360
Citations number
29
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Context Continuous positive airway pressure (CPAP) is widely used in the be
lief that it may reduce the need for intubation and mechanical ventilation
in patients with acute hypoxemic respiratory insufficiency.
Objective To compare the physiologic effects and the clinical efficacy of C
PAP vs standard oxygen therapy in patients with acute hypoxemic, nonhyperca
pnic respiratory insufficiency.
Design, Setting, and Patients Randomized, concealed, and unblinded trial of
123 consecutive adult patients who were admitted to 6 intensive care units
between September 1997 and January 1999 with a PaO2/FIO2 ratio of 300 mm H
g or less due to bilateral pulmonary edema (n=102 with acute lung injury an
d n=21 with cardiac disease).
Interventions Patients were randomly assigned to receive oxygen therapy alo
ne (n=61) or oxygen therapy plus CPAP (n=62).
Main Outcome Measures Improvement in PaO2/FIO2 ratio, rate of endotracheal
intubation at any time during the study, adverse events, length of hospital
stay, mortality, and duration of ventilatory assistance, compared between
the CPAP and standard treatment groups.
Results Among the CPAP vs standard therapy groups, respectively, causes of
respiratory failure (pneumonia, 54% and 55%), presence of cardiac disease (
33% and 35%), severity at admission, and hypoxemia (median [5th-95th percen
tile] PaO2/FIO2 ratio, 140 [59-288] mm Hg vs 148 [62-283] mm Hg; P=.43) wer
e similarly distributed. After 1 hour of treatment, subjective responses to
treatment (P<.001) and median (5th-95th percentile) PaO2/FIO2 ratios were
greater with CPAP (203 [45-431] mm Hg vs 151 [73-482] mm Hg; P=.02), No fur
ther difference in respiratory indices was observed between the groups. Tre
atment with CPAP failed to reduce the endotracheal intubation rate (21 [34%
] vs 24 [39%] in the standard therapy group; P=.53), hospital mortality (19
[31%] vs 18 [30%]; P=.89), or median (5th-95th percentile) intensive care
unit length of stay (6.5 [1-57] days vs 6.0 [1-36] days; P=.43), A higher n
umber of adverse events occurred with CPAP treatment (18 vs 6; P=.01),
Conclusion In this study, despite early physiologic improvement, CPAP neith
er reduced the need for intubation nor improved outcomes in patients with a
cute hypoxemic, nonhypercapnic respiratory insufficiency primarily due to a
cute lung injury.