Dimethyl acetylsuccinate as a versatile synthon in heterocyclic chemistry - A facile synthesis of heterocyclic acetic acid derivatives

The preparation of novel acetic acid derivatives of pyrazole 3a,b and pyrim idine 2a-e is achieved by condensation of dimethyl acetylsuccinate (1) with appropriate reaction partners. Also triethyl 1,1,2-ethanetricarboxylate (6 ) is a valuable starting material, which is demonstrated by the synthesis o f previously unknown pyrimidin-5-yl acetates.