6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases

Authors
Golemi, D Maveyraud, L Ishiwata, A Tranier, S Miyashita, K Nagase, T Massova, I Mourey, L Samama, JP Mobashery, S
Citation
D. Golemi et al., 6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases, J ANTIBIOT, 53(10), 2000, pp. 1022-1027
Citations number
19
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
10
Year of publication
2000
Pages
1022 - 1027
Database
ISI
SICI code
0021-8820(200010)53:10<1022:6APFMO>2.0.ZU;2-9
Abstract
6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the me cha n isms of beta -lactamases, enzymes of resistance for beta -lactam antibiot ics. The present report summarizes the concepts on design, syntheses and us e of these molecules in mechanistic studies of beta -lactamases.