Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp MK929-43F1 - Taxonomy, fermentation, isolation and biological activities

Authors
Nakae, K Yoshimoto, Y Sawa, T Homma, Y Hamada, M Takeuchi, T Imoto, M
Citation
K. Nakae et al., Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp MK929-43F1 - Taxonomy, fermentation, isolation and biological activities, J ANTIBIOT, 53(10), 2000, pp. 1130-1136
Citations number
15
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
10
Year of publication
2000
Pages
1130 - 1136
Database
ISI
SICI code
0021-8820(200010)53:10<1130:MANIOT>2.0.ZU;2-4
Abstract
A new compound, migrastatin, was isolated from a cultured broth of Streptom yces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purifi ed by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Mi grastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of hum an esophageal cancer EC17 cells. Migration inhibitory activity of migrastat in was not dependent on cytotoxicity or inhibition of protein synthesis.