SUBCELLULAR ANALYSIS OF BORON WITH A NUCLEAR MICROPROBE

Authors
SJOLAND KA KRISTIANSSON P ELFMAN M MALMQVIST KG PALLON J UTUI RJ YANG C
Citation
Ka. Sjoland et al., SUBCELLULAR ANALYSIS OF BORON WITH A NUCLEAR MICROPROBE, Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, 129(1), 1997, pp. 101-105
Citations number
11
Categorie Soggetti
Physics, Nuclear","Nuclear Sciences & Tecnology","Instument & Instrumentation
Journal title
Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms → ACNP
ISSN journal
0168583X
Volume
129
Issue
1
Year of publication
1997
Pages
101 - 105
Database
ISI
SICI code
0168-583X(1997)129:1<101:SAOBWA>2.0.ZU;2-0
Abstract
The boron distribution in cells from a rat brain, into which a boron c ompound (BOPP) had been injected in the context of Boron Neutron Captu re Therapy (BNCT), was analyzed with a nuclear microprobe by Nuclear R eaction Analysis. The B-11(p,alpha)Be reaction was utilized at the re sonance at 0.63 MeV. Boron images and Scanning Transmission Ion Micros copy (STIM) images were recorded and evaluated by various methods. The sample preparation was straightforward and introduced only a minimum of steps which could potentially interfere with the result. Methods to to compare different boron compounds for BNCT are suggested. The boro n was distributed fairly evenly in the cells. The average boron concen tration was about 7 ppm dry weight, and the variation over individual cells small.