Trends and regional differences in coronary risk factors in two areas in Belgium: final results from the MONICA Ghent-Charleroi study

Objective To study regional differences and trends in coronary risk factors and in predicted coronary risk calculated on the basis of multiple logisti c function equations for the general population aged 25-64 years in two are as in Belgium during the period 1985-1992. Design A comparison of cross-sectional data on coronary risk factors betwee n two cities and different survey periods. Method In the cities of Ghent (in Flanders) and Charleroi (in Walloonia) in Belgium, three consecutive cross-sectional age-stratified and sex-stratifi ed random samples of 2000 subjects each were selected from the general popu lation. We studied their coronary risk factors between 1985 and 1992. The f ield work was carried out according to the protocol of the international WH O-MONICA project. Results We observed a significant decrease in the prevalence of smoking amo ng men in the two cities over the three surveys, while a gradual increase i n diastolic blood pressure for all subgroups in Ghent was seen (this was st atistically significant for men aged 45-64 years and women aged 25-44 years ). The overall coronary risk predicted on the basis of multiple-logistic-fu nction equations did not however, exhibit significant trends over time in e ither city. Comparisons between the two centres revealed significantly high er mean serum levels of total cholesterol in Charleroi than in Ghent (for a ll subgroups except women aged 45-64 years) and significantly higher mean s ystolic blood pressures in Charleroi for all subgroups defined in terms of age and sex. Prevalences of hypertension in Ghent were significantly lower than those in Charleroi for individuals aged 25-44 years, while the prevale nce of obesity in all subgroups in Ghent was also significantly lower. The overall predicted coronary risk in Charleroi was also significantly higher, except for men aged 45-64 years. The differences in mean predicted risk ra nged from 5.0% for men aged 45-64 years to 21.2% for women aged 45-64 years . Conclusions From the data in this article it seems that the trends in overa ll coronary risk profiles in Ghent and Charleroi are not in accordance with the observed trends in incidence of coronary heart disease (CHD) in these two cities. On the other hand, the differences in predicted coronary risk b etween the two cities are in the same direction as the observed differences in incidence of CHD between the two cities, but are however too small to e xplain fully the observed difference in incidence of CHD between the two ce ntres. (C) Lippincott Williams & Wilkins.