POSTOPERATIVE DELIRIUM EASILY DEVELOPS IN PATIENTS WITH INTRAMITOCHONDRIAL INCLUSION-BODIES IN COLONIC NEURONS

Patients whose colons were resected for carcinoma were studied in orde r to determine the relationship between clinical findings - which incl uded development of postoperative delirium - and intramitochondrial in clusion bodies (MI) in the neurons in the colon. Twenty-three patients had MI and 24 patients did not. Preoperative dementia was present in 9 (39.1%) of the 23 patients with MI, and in 7 (29.2%) of the 24 witho ut it. Postoperative delirium developed in 13 (56.3%) of the 23 with M I, and in 5 (20.8%) of the 24 without it (p<0.05). Excluding preoperat ive dementia, postoperative delirium developed in 5 (35.7%) of the 14 with MI, and in none of the 17 without it. Changes in the neurons in t he colon were not related to dementia. The changes may have been relat ed to the functions of the central nervous system, because patients wi th MI were likely to develop postoperative delirium. (C) 1997, Editric e Kurtis.