Clinical rubella reinfection during pregnancy in a previously vaccinated woman

We report a documented case of clinically apparent rubella reinfection duri ng pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemaggl utination inhibition (HI) antibody titre of 1:32. The serological tests res ults (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In a ddition, rubella-specific IgG antibody avidity testing displayed high avidi ty index (53-88%) typical of rubella reinfection, Umbilical cord blood, dra wn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody The pregnancy was continued to term, and a healthy infant was born, (C) 2000 The British Infection Soci ety.