Technetium-99m MDP bone scintigraphic findings of hypercalcemia in accelerated phase of chronic myelogenous leukemia

Hypercalcemia in accelerated phase of chronic myelogenous leukemia (CML) is very rare. Its pathogenesis is considered humoral hypercalcemia of maligna ncies mediated by parathyroid hormone-related protein (PTHrP). In severe hy percalcemia, calcifications in kidneys, skin, vessels, heart, and stomach m ay occur, Our two cases were admitted because of severe hypercalcemia in ac celerated phase of CML. On Tc-99m methylene diphosphonate (MDP) bone scinti graphies, a marked tracer accumulation was seen in the lung, heart, stomach and kidney. We report increased tracer accumulation of multiple organs on Tc-99m MDP bone scintigraphy in two rare hypercalcemic patients with CML.