Syntheses of two [C-14]-labeled disodium 4-[(N-tert-butylimino)methyl]benzene-1,3-disulfonate N-oxides

Authors
Johansson, R Werner, T
Citation
R. Johansson et T. Werner, Syntheses of two [C-14]-labeled disodium 4-[(N-tert-butylimino)methyl]benzene-1,3-disulfonate N-oxides, J LABEL C R, 43(13), 2000, pp. 1265-1273
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
13
Year of publication
2000
Pages
1265 - 1273
Database
ISI
SICI code
0362-4803(200011)43:13<1265:SOT[D4>2.0.ZU;2-S
Abstract
NXY-059 (5) is a new chemical entity developed as a putative agent for the treatment of acute and chronic neurological degenerative disorders. It is c urrently undergoing clinical evaluation for the treatment of stroke. In ord er to study the metabolic transformation and organ distribution of the comp ound, radiolabeled NXY-059 was needed. In this paper; we describe the synth esis of two differently carbon-14 labeled disodium 4-[(N-tert-butylimino)me thyl]benzene-1,3-disulfonate N-oxides.