Acute renal failure due to idiopathic tubulo-interstitial nephritis and uveitis: "TINU syndrome" - Case report and review of the literature

Acute renal failure due to idiopathic tubulo-interstitial nephritis associa ted with bilateral uveitis (TINU syndrome) is a rare clinical event, contra cted mainly by girls or women. Here we report the clinical follow-up regard ing a 22-year-old woman with acute renal failure (creat, clearance 13.5 ml/ min) due to idiopathic tubulo-interstitial nephritis documented by renal bi opsy, after bilateral uveitis which healed with local prednisone. The clini cal history and the clinical follow-up of our patient were typical of the T INU syndrome. We were able to exclude all diseases causing acute tubulo-int erstitial nephritis such as systemic infection, hypersensitivity to drugs, Behcet's disease, Sjogren syndrome, sarcoidosis, systemic lupus or vasculit ides. The patient recovered after systemic prednisone.