Dysregulation of the hypothalamic-pituitary-adrenal axis in short childrenwith and without growth hormone deficiency

Authors
Stratakis, CA Rusovici, DE Kulin, HE Finkelstein, JW
Citation
Ca. Stratakis et al., Dysregulation of the hypothalamic-pituitary-adrenal axis in short childrenwith and without growth hormone deficiency, J PED END M, 13(8), 2000, pp. 1095-1100
Citations number
24
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
ISSN journal
0334018X → ACNP
Volume
13
Issue
8
Year of publication
2000
Pages
1095 - 1100
Database
ISI
SICI code
0334-018X(200009/10)13:8<1095:DOTHAI>2.0.ZU;2-M
Abstract
The effects of L-dopamine (LD) administration and insulin-induced hypoglyce mia in adrenocorticotropin (ACTH) and cortisol secretion were studied in 14 short boys. LD caused moderate changes in both hormones. The four boys wit h isolated, idiopathic growth hormone (GH) deficiency (IGD) demonstrated a greater cortisol increase in response to hypoglycemia than the 10 boys with normal GH secretion. In at least some short children with IGD, abnormal re gulation of the hypothalamic-pituitary-adrenal axis may be present.