Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: A report from the CHAMP study group

Whether fibromatoses are neoplastic or reactive lesions has long been contr oversial and the relationship, if any, between the superficial and deep for ms (desmoid tumors) are poorly understood. Clinical, pathologic, and cytoge netic data of 78 cases of fibromatosis were analyzed and correlated with ea ch other. The results demonstrate that clonal chromosome aberrations are a common feature of this entity, being present in 46% of desmoid tumors, alth ough less frequent in the superficial types (10%). In the deep-seated extra -abdominal fibromatoses, trisomies 8 and 20 and loss of 58 material were th e only recurrent features. No correlation between +8 and local recurrence w as found. Our findings provide additional evidence for the neoplastic natur e of fibromatoses.