Molecular characterization of two new Drosophila melanogaster homologs of human TAF(II)30

Authors
Nabirochkina, EN Soldatov, AV Georgieva, SG
Citation
En. Nabirochkina et al., Molecular characterization of two new Drosophila melanogaster homologs of human TAF(II)30, MOL BIOL, 34(5), 2000, pp. 662-666
Citations number
24
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
34
Issue
5
Year of publication
2000
Pages
662 - 666
Database
ISI
SICI code
0026-8933(200009/10)34:5<662:MCOTND>2.0.ZU;2-E
Abstract
Two new homologs of human (h) TAF(II)30, dTAF(II)16 and dTAF(II)24 were rev ealed in Drosophila melanogaster: The proteins are encoded by neighboring g enes and bind with the TATA-binding protein and other dTAF(II) proteins inv olved in TFIID. Only dTAF(II)24 interacts with GCN5 histone acetyltransfera se (HAT), which is the first demonstration of the TAF(II)-GCN5-HAT complex in D. melanogaster. The two proteins have both common and individual locati on sites on polytene chromosomes. Possibly, the functions of dTAF(II)16 and dTAF(II)24 are similar but not identical.